C-KIT mutation cooperates with full-length AML1-ETO to induce acute myeloid leukemia in mice

The full-length AML1-ETO (AE) fusion gene resulting from t(8;21)(q22;q22) in human acute myeloid leukemia (AML) is not sufficient to induce leukemia in animals, suggesting that additional mutations are required for leukemogenesis. We and others have identified activating mutations of C-KIT in nearly...

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Bibliographic Details
Main Authors: Wang, Yue-Ying, Zhao, Li-Juan, Wu, Chuan-Feng, Liu, Ping, Shi, Lin, Liang, Yang, Xiong, Shu-Min, Mi, Jian-Qing, Chen, Zhu, Ren, Ruibao, Chen, Sai-Juan
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038718/
https://ncbi.nlm.nih.gov/pubmed/21262832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019625108
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