Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active

ERK1 and ERK2 (ERK1/2) are central to the regulation of cell division, growth and survival. They are activated by phosphorylation of the Thr- and the Tyr- residues in their Thr-Glu-Tyr activation loops. The dogma is that dually-phosphorylated ERK1/2 constitute the principal activities in intact cell...

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Main Authors: Sugden, Peter H., Markou, Thomais, Fuller, Stephen J., Tham, El Li, Molkentin, Jeffery D., Paterson, Hugh F., Clerk, Angela
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier Science Ltd 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038257/
https://ncbi.nlm.nih.gov/pubmed/21044683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2010.10.024
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