Anchorage-independent growth of synoviocytes from arthritic and normal joints. Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-beta and retinoids.

Exuberant tumor-like synovial cell proliferation with invasion of periarticular bone is a feature of rheumatoid arthritis in humans and of streptococcal cell wall (SCW)-induced arthritis in rats. These histologic observations prompted us to examine synoviocytes from arthritic joints for phenotypic c...

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Autori principali: Lafyatis, R, Remmers, E F, Roberts, A B, Yocum, D E, Sporn, M B, Wilder, R L
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1989
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC303817/
https://ncbi.nlm.nih.gov/pubmed/2784799
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