Induced fit DNA recognition by a minor groove binding analogue of Hoechst 33258: fluctuations in DNA A tract structure investigated by NMR and molecular dynamics simulations

NMR analysis and molecular dynamics simulations of d(GGTAATTACC)(2) and its complex with a tetrahydropyrimidinium analogue of Hoechst 33258 suggest that DNA minor groove recognition in solution involves a combination of conformational selection and induced fit, rather than binding to a preorganised...

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Detalles Bibliográficos

Publicado en:	Nucleic Acids Res
Principais autores:	Bostock-Smith, Clare E., Harris, Sarah A., Laughton, Charles A., Searle, Mark S.
Formato:	Artigo
Idioma:	Inglês
Publicado:	Oxford University Press 2001
Assuntos:	Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30379/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11160891/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.3.693
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