Induced fit DNA recognition by a minor groove binding analogue of Hoechst 33258: fluctuations in DNA A tract structure investigated by NMR and molecular dynamics simulations

NMR analysis and molecular dynamics simulations of d(GGTAATTACC)(2) and its complex with a tetrahydropyrimidinium analogue of Hoechst 33258 suggest that DNA minor groove recognition in solution involves a combination of conformational selection and induced fit, rather than binding to a preorganised...

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Autores principales: Bostock-Smith, Clare E., Harris, Sarah A., Laughton, Charles A., Searle, Mark S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2001
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC30379/
https://ncbi.nlm.nih.gov/pubmed/11160891
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