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Sequence-dependent variation in DNA minor groove width dictates orientational preference of Hoechst 33258 in A-tract recognition: solution NMR structure of the 2:1 complex with d(CTTTTGCAAAAG)(2)

The solution structure of the dodecamer duplex d(CTTTTGCAAAAG)(2) and its 2:1 complex with the bis-benzimidazole Hoechst 33258 has been investigated by NMR and NOE-restrained molecular dynamics (rMD) simulations. Drug molecules are bound in each of the two A-tracts with the bulky N-methylpiperazine...

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Библиографические подробности
Главные авторы: Gavathiotis, Evripidis, Sharman, Gary J., Searle, Mark S.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2000
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC102559/
https://ncbi.nlm.nih.gov/pubmed/10637324
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