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Activity of BK(Ca) Channel Is Modulated by Membrane Cholesterol Content and Association with Na(+)/K(+)-ATPase in Human Melanoma IGR39 Cells

Interaction of large conductance Ca(2+)- and voltage-activated K(+) (BK(Ca)) channels with Na(+)/K(+)-ATPase, caveolin-1, and cholesterol was studied in human melanoma IGR39 cells. Functional BK(Ca) channels were enriched in caveolin-rich and detergent-resistant membranes, i.e. rafts, and blocking o...

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Detalhes bibliográficos
Main Authors: Tajima, Nobuyoshi, Itokazu, Yutaka, Korpi, Esa R., Somerharju, Pentti, Käkelä, Reijo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037676/
https://ncbi.nlm.nih.gov/pubmed/21135099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.149898
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