Transcription Factor IIS Cooperates with the E3 Ligase UBR5 to Ubiquitinate the CDK9 Subunit of the Positive Transcription Elongation Factor B

Elongation of transcription by mammalian RNA polymerase II (RNAPII) is regulated by specific factors, including transcription factor IIS (TFIIS) and positive transcription elongation factor b (P-TEFb). We show that the E3 ubiquitin ligase UBR5 associates with the CDK9 subunit of positive transcripti...

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Main Authors: Cojocaru, Marilena, Bouchard, Annie, Cloutier, Philippe, Cooper, Jeff J., Varzavand, Katayoun, Price, David H., Coulombe, Benoit
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Gene Regulation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037613/
https://ncbi.nlm.nih.gov/pubmed/21127351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.176628
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