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A diabetes-susceptible HLA haplotype is best defined by a combination of HLA-DR and -DQ alleles.
HLA-DR4 is associated with insulin-dependent diabetes mellitus (IDDM) in many populations. Many recent studies suggest that the DR4 effect is really due to DQ3.2, an allele of the nearby DQB1 locus. We used T cell clones, MAb, and allele-specific oligonucleotides to test IDDM and control subjects fo...
Guardat en:
| Publicat a: | J Clin Invest |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Clinical Investigation
1989
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303755/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2784133/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113965 |
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