A diabetes-susceptible HLA haplotype is best defined by a combination of HLA-DR and -DQ alleles.

HLA-DR4 is associated with insulin-dependent diabetes mellitus (IDDM) in many populations. Many recent studies suggest that the DR4 effect is really due to DQ3.2, an allele of the nearby DQB1 locus. We used T cell clones, MAb, and allele-specific oligonucleotides to test IDDM and control subjects fo...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Sheehy, M J, Scharf, S J, Rowe, J R, Neme de Gimenez, M H, Meske, L M, Erlich, H A, Nepom, B S
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1989
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303755/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2784133/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113965
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