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Silk-Based Gene Carriers with Cell Membrane-Destabilizing Peptides
Complexes of recombinant silk-polylysine molecules with ppTG1 peptide, a lysine-rich cell membrane-destabilizing peptide to bind plasmid DNA (pDNA), are designed as less-cytotoxic and highly efficient gene carriers. The peptide destabilizes the cell membrane and promotes gene transfer. Our particula...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3037451/ https://ncbi.nlm.nih.gov/pubmed/20942485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bm101055m |
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