Relationship between Functional Profile of HIV-1 Specific CD8 T Cells and Epitope Variability with the Selection of Escape Mutants in Acute HIV-1 Infection

In the present study, we analyzed the functional profile of CD8(+) T-cell responses directed against autologous transmitted/founder HIV-1 isolates during acute and early infection, and examined whether multifunctionality is required for selection of virus escape mutations. Seven anti-retroviral ther...

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Hlavní autoři: Ferrari, Guido, Korber, Bette, Goonetilleke, Nilu, Liu, Michael K. P., Turnbull, Emma L., Salazar-Gonzalez, Jesus F., Hawkins, Natalie, Self, Steve, Watson, Sydeaka, Betts, Michael R., Gay, Cynthia, McGhee, Kara, Pellegrino, Pierre, Williams, Ian, Tomaras, Georgia D., Haynes, Barton F., Gray, Clive M., Borrow, Persephone, Roederer, Mario, McMichael, Andrew J., Weinhold, Kent J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037354/
https://ncbi.nlm.nih.gov/pubmed/21347345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001273
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