Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation

BACKGROUND: Previously we reported 1 μM synthetic human amyloid beta(1-42 )oligomers induced cofilin dephosphorylation (activation) and formation of cofilin-actin rods within rat hippocampal neurons primarily localized to the dentate gyrus. RESULTS: Here we demonstrate that a gel filtration fraction...

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Autores principales: Davis, Richard C, Marsden, Ian T, Maloney, Michael T, Minamide, Laurie S, Podlisny, Marcia, Selkoe, Dennis J, Bamburg, James R
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037337/
https://ncbi.nlm.nih.gov/pubmed/21261978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-10
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