Analysis of Genetic Inheritance in a Family Quartet by Whole Genome Sequencing

We analyzed the whole genome sequences of a family of four, consisting of two siblings and their parents. Family-based sequencing allowed us to delineate recombination sites precisely, identify 70% of the sequencing errors, and identify very rare SNVs. We also directly estimated a human intergenerat...

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Detalhes bibliográficos
Main Authors: Roach, Jared C., Glusman, Gustavo, Smit, Arian F.A., Huff, Chad D., Hubley, Robert, Shannon, Paul T., Rowen, Lee, Pant, Krishna P., Goodman, Nathan, Bamshad, Michael, Shendure, Jay, Drmanac, Radoje, Jorde, Lynn B., Hood, Leroy, Galas, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037280/
https://ncbi.nlm.nih.gov/pubmed/20220176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1186802
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