Analysis of Genetic Inheritance in a Family Quartet by Whole Genome Sequencing

We analyzed the whole genome sequences of a family of four, consisting of two siblings and their parents. Family-based sequencing allowed us to delineate recombination sites precisely, identify 70% of the sequencing errors, and identify very rare SNVs. We also directly estimated a human intergenerat...

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Detalles Bibliográficos
Autores principales: Roach, Jared C., Glusman, Gustavo, Smit, Arian F.A., Huff, Chad D., Hubley, Robert, Shannon, Paul T., Rowen, Lee, Pant, Krishna P., Goodman, Nathan, Bamshad, Michael, Shendure, Jay, Drmanac, Radoje, Jorde, Lynn B., Hood, Leroy, Galas, David J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037280/
https://ncbi.nlm.nih.gov/pubmed/20220176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1186802
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