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Loss of Canonical Insulin Signaling Accelerates Vascular Smooth Muscle Cell Proliferation and Migration Through Changes in p27(Kip1) Regulation

Insulin resistance is associated with an accelerated rate of atherosclerosis. Vascular smooth muscle cell (VSMC) migration and proliferation are important components of atherosclerosis. To elucidate the effects of the loss of normal insulin receptor (IR) signaling on VSMC function, we compared the p...

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Main Authors: Lightell, Daniel James, Moss, Stephanie Collier, Woods, Thomas Cooper
Formato: Artigo
Idioma:Inglês
Publicado: Endocrine Society 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037159/
https://ncbi.nlm.nih.gov/pubmed/21190963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0722
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