RNAi-mediated silencing of the Bmi-1 gene causes growth inhibition and enhances doxorubicin-induced apoptosis in MCF-7 cells

The oncogene Bmi-1 is a member of the Polycomb group gene family. Its expression is found to be greatly increased in a number of malignant tumors including breast cancer. This could suggest Bmi-1 as a potent therapeutic target. In this study, RNAi was introduced to down-regulate the expression of Bm...

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Hlavní autoři: Wu, Xiang-mei, Liu, Xing, Bu, You-quan, Sengupta, Joyeeta, Cui, Hong-juan, Yi, Fa-ping, Liu, Tao, Yuan, Chen-fu, Shi, Yan-yan, Song, Fang-zhou
Médium: Artigo
Jazyk:Inglês
Vydáno: Sociedade Brasileira de Genética 2009
Témata:
Human and Medical Genetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3036904/
https://ncbi.nlm.nih.gov/pubmed/21637439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/S1415-47572009005000092
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