Fibrinogen-independent platelet adhesion and thrombus formation on subendothelium mediated by glycoprotein IIb-IIIa complex at high shear rate.

Platelet adhesion and thrombus formation on subendothelium, studied at a shear rate of 2,600 s-1, were inhibited by two synthetic peptides known to interact with GPIIb-IIIa. One peptide (HHLGGAKQAGDV) corresponds to the carboxyl terminal segment of the fibrinogen gamma-chain (gamma 400-411) and the...

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Bibliographische Detailangaben
Veröffentlicht in:J Clin Invest
Hauptverfasser: Weiss, H J, Hawiger, J, Ruggeri, Z M, Turitto, V T, Thiagarajan, P, Hoffmann, T
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 1989
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303673/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2910912/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113871
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