Successful Targeting and Disruption of an Integrated Reporter Lentivirus Using the Engineered Homing Endonuclease Y2 I-AniI

Current antiviral therapy does not cure HIV-infected individuals because the virus establishes lifelong latent infection within long-lived memory T cells as integrated HIV proviral DNA. Here, we report a new therapeutic approach that aims to cure cells of latent HIV infection by rendering latent vir...

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Bibliografiske detaljer
Main Authors: Aubert, Martine, Ryu, Byoung Y., Banks, Lindsey, Rawlings, David J., Scharenberg, Andrew M., Jerome, Keith R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3036713/
https://ncbi.nlm.nih.gov/pubmed/21399673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016825
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