Genetic Variants in ABCB1, CYP2C19, and Cardiovascular Outcomes Following Treatment with Clopidogrel and Prasugrel

BACKGROUND: The thienopyridine clopidogrel is one of the most commonly prescribed drugs worldwide. Both clopidogrel and the third-generation thienopyridine prasugrel are subject to efflux via P-glycoprotein (encoded by ABCB1, also known as MDR1). In vitro and clinical studies suggest that ABCB1 poly...

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Главные авторы: Mega, Jessica L., Close, Sandra L., Wiviott, Stephen D., Shen, Lei, Walker, Joseph R., Simone, Tabassome, Antman, Elliott M., Braunwald, Eugene, Sabatine, Marc S.
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3036672/
https://ncbi.nlm.nih.gov/pubmed/20801494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(10)61273-1
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