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Two TPX2-Dependent Switches Control the Activity of Aurora A
Aurora A is an important oncogenic kinase for mitotic spindle assembly and a potentially attractive target for human cancers. Its activation could be regulated by ATP cycle and its activator TPX2. To understand the activation mechanism of Aurora A, a series of 20 ns molecular dynamics (MD) simulatio...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3036663/ https://ncbi.nlm.nih.gov/pubmed/21347367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016757 |
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