Human autoantibodies to poly(adenosine diphosphate-ribose) polymerase recognize cross-reactive epitopes associated with the catalytic site of the enzyme.

The factors responsible for the production of autoantibodies against self-components are not well understood. We have identified monospecific human autoantibodies to poly(ADP-ribose) polymerase (ADPRP) in the sera of rheumatic patients. Since this nuclear enzyme has been extensively characterized, a...

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Pubblicato in:	J Clin Invest
Autori principali:	Yamanaka, H, Willis, E H, Carson, D A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1989
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303659/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2463266/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113856
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