Micronuclei induced by reverse transcriptase inhibitors in mononucleated and binucleated cells as assessed by the cytokinesis-block micronucleus assay

This study evaluated the clastogenic and/or aneugenic potential of three nucleoside reverse transcriptase inhibitors (zidovudine - AZT, lamivudine - 3TC and stavudine - d4T) using the cytokinesis-block micronucleus (CBMN) assay in human lymphocyte cultures. All three inhibitors produced a positive r...

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Hlavní autoři: Lourenço, Eloir D., do Amaral, Viviane S., Lehmann, Mauricio, Dihl, Rafael R., Schmitt, Virginia M., Cunha, Kênya S., Reguly, Maria L., de Andrade, Heloisa H. R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Sociedade Brasileira de Genética 2010
Témata:
Mutagenesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3036155/
https://ncbi.nlm.nih.gov/pubmed/21637587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/S1415-47572010005000084
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