Alterations of brain and cerebellar proteomes linked to Aβ and tau pathology in a female triple-transgenic murine model of Alzheimer's disease

The triple-transgenic Alzheimer (3 × Tg-AD) mouse expresses mutant PS1(M146V), APP(swe), and tau(P301L) transgenes and progressively develops plaques and neurofibrillary tangles with a temporal- and region-specific profile that resembles the neuropathological progression of Alzheimer's disease...

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Detalhes bibliográficos
Main Authors: Ciavardelli, D, Silvestri, E, Viscovo, A Del, Bomba, M, Gregorio, D De, Moreno, M, Ilio, C Di, Goglia, F, Canzoniero, L M T, Sensi, S L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035905/
https://ncbi.nlm.nih.gov/pubmed/21368863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2010.68
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