Experimentally Approaching the ICU: Monitoring Outcome-Based Responses in the Two-Hit Mouse Model of Posttraumatic Sepsis

To simulate and monitor the evolution of posttraumatic sepsis in mice, we combined a two-hit model of trauma/hemorrhage (TH) followed by polymicrobial sepsis with repetitive blood sampling. Anesthetized mice underwent femur fracture/sublethal hemorrhage and cecal ligation and puncture (CLP) 48 h lat...

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Bibliographic Details
Main Authors: Drechsler, Susanne, Weixelbaumer, Katrin M., Redl, Heinz, van Griensven, Martijn, Bahrami, Soheyl, Osuchowski, Marcin F.
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2011
Subjects:
Methodology Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035807/
https://ncbi.nlm.nih.gov/pubmed/21318073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/357926
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