Constrained Pattern of Viral Evolution in Acute and Early HCV Infection Limits Viral Plasticity

Cellular immune responses during acute Hepatitis C virus (HCV) and HIV infection are a known correlate of infection outcome. Viral adaptation to these responses via mutation(s) within CD8+ T-cell epitopes allows these viruses to subvert host immune control. This study examined HCV evolution in 21 HC...

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Main Authors: Pfafferott, Katja, Gaudieri, Silvana, Ulsenheimer, Axel, James, Ian, Heeg, Malte, Nolan, David, John, Mina, Rauch, Andri, Mallal, Simon, Lucas, Andrew, Klenerman, Paul, Diepolder, Helmut M., Lucas, Michaela
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035653/
https://ncbi.nlm.nih.gov/pubmed/21347433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016797
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