PAR4, but Not PAR1, Signals Human Platelet Aggregation via Ca(2+) Mobilization and Synergistic P2Y(12) Receptor Activation

Regulation of platelet activation plays a central role in hemostasis and pathophysiological processes such as coronary artery disease. Thrombin is the most potent activator of platelets. Human platelets express two thrombin receptors, PAR1 and PAR4, both of which signal platelet activation. Evidence...

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Hauptverfasser: Holinstat, Michael, Voss, Bryan, Bilodeau, Matthew L., McLaughlin, Joseph N., Cleator, John, Hamm, Heidi E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035573/
https://ncbi.nlm.nih.gov/pubmed/16837456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M602174200
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