Administration of an aldose reductase inhibitor induces a decrease of collagen fluorescence in diabetic rats.

As a consequence of an increased flux through the sorbitol pathway fructose levels rise in various tissues in diabetes. Also, in vitro nonenzymatic fructosylation of protein induces the generation of fluorescence at a rate 10 times greater than glucosylation. The administration of sorbinil, an aldos...

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Publié dans:	J Clin Invest
Auteurs principaux:	Suárez, G, Rajaram, R, Bhuyan, K C, Oronsky, A L, Goidl, J A
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Clinical Investigation 1988
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303557/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3136193/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113641
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