Administration of an aldose reductase inhibitor induces a decrease of collagen fluorescence in diabetic rats.
As a consequence of an increased flux through the sorbitol pathway fructose levels rise in various tissues in diabetes. Also, in vitro nonenzymatic fructosylation of protein induces the generation of fluorescence at a rate 10 times greater than glucosylation. The administration of sorbinil, an aldos...
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| Publicado no: | J Clin Invest |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
1988
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303557/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3136193/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113641 |
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