Functional analysis of the missense APOC3 mutation Ala23Thr associated with human hypotriglyceridemia

We have shown that expression of apolipoprotein (apo) C-III promotes VLDL secretion from transfected McA-RH7777 cells under lipid-rich conditions. To determine structural elements within apoC-III that confer to this function, we contrasted wild-type apoC-III with a mutant Ala23Thr originally identif...

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Hauptverfasser: Sundaram, Meenakshi, Zhong, Shumei, Khalil, Maroun Bou, Zhou, Hu, Jiang, Zhenghui G., Zhao, Yang, Iqbal, Jahangir, Hussain, M. Mahmood, Figeys, Daniel, Wang, Yuwei, Yao, Zemin
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035516/
https://ncbi.nlm.nih.gov/pubmed/20097930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M005108
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