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Functional analysis of the missense APOC3 mutation Ala23Thr associated with human hypotriglyceridemia
We have shown that expression of apolipoprotein (apo) C-III promotes VLDL secretion from transfected McA-RH7777 cells under lipid-rich conditions. To determine structural elements within apoC-III that confer to this function, we contrasted wild-type apoC-III with a mutant Ala23Thr originally identif...
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| Hauptverfasser: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The American Society for Biochemistry and Molecular Biology
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3035516/ https://ncbi.nlm.nih.gov/pubmed/20097930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M005108 |
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