Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency.

Although several genetic defects are known to impair oxidative microbicidal/cytotoxic mechanisms in human PMN, no deficiencies of PMN granule components that mediate oxygen-independent microbicidal activity have yet been reported. We analyzed PMN from patients with various granulocyte disorders for...

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Pubblicato in:	J Clin Invest
Autori principali:	Ganz, T, Metcalf, J A, Gallin, J I, Boxer, L A, Lehrer, R I
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1988
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303547/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2841356/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113631
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