Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone.

Recent studies suggest that oxygen free radicals may mediate postischemic myocardial dysfunction ("stunning"), but all the evidence for this hypothesis is indirect. Thus, we used electron paramagnetic resonance (EPR) spectroscopy and the spin trap, alpha-phenyl N-tert-butyl nitrone (PBN), to directl...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Bolli, R, Patel, B S, Jeroudi, M O, Lai, E K, McCay, P B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1988
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303537/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2841353/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113621
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