Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone.

Recent studies suggest that oxygen free radicals may mediate postischemic myocardial dysfunction ("stunning"), but all the evidence for this hypothesis is indirect. Thus, we used electron paramagnetic resonance (EPR) spectroscopy and the spin trap, alpha-phenyl N-tert-butyl nitrone (PBN),...

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Bibliographic Details
Main Authors: Bolli, R, Patel, B S, Jeroudi, M O, Lai, E K, McCay, P B
Format: Artigo
Language:Inglês
Published: 1988
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC303537/
https://ncbi.nlm.nih.gov/pubmed/2841353
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