Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle.

The first adult case of 11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) deficiency is described. The impaired conversion of cortisol to cortisone (indicated by urinary cortisol and cortisone metabolites and failure to metabolize 11 alpha-[3H]cortisol to [3H]H2O), was associated with hypertension...

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Pubblicato in:	J Clin Invest
Autori principali:	Stewart, P M, Corrie, J E, Shackleton, C H, Edwards, C R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1988
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303514/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3164727/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI113592
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