The Bcl-2 Gene Polymorphism rs956572AA Increases Inositol 1,4,5-Trisphosphate Receptor–Mediated Endoplasmic Reticulum Calcium Release in Subjects with Bipolar Disorder

BACKGROUND: Bipolar disorder (BPD) is characterized by altered intracellular calcium (Ca(2+)) homeostasis. Underlying mechanisms involve dysfunctions in endoplasmic reticulum (ER) and mitochondrial Ca(2+) handling, potentially mediated by B-cell lymphoma 2 (Bcl-2), a key protein that regulates Ca(2+...

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Main Authors: Machado-Vieira, Rodrigo, Pivovarova, Natalia B., Stanika, Ruslan I., Yuan, Peixiong, Wang, Yun, Zhou, Rulun, Zarate, Carlos A., Drevets, Wayne C., Brantner, Christine A., Baum, Amber, Laje, Gonzalo, McMahon, Francis J., Chen, Guang, Du, Jing, Manji, Husseini K., Andrews, S. Brian
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035040/
https://ncbi.nlm.nih.gov/pubmed/21167476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2010.10.019
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