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Formation of Toxic Amyloid Fibrils by Amyloid β-Protein on Ganglioside Clusters

It is widely accepted that the conversion of the soluble, nontoxic amyloid β-protein (Aβ) monomer to aggregated toxic Aβ rich in β-sheet structures is central to the development of Alzheimer's disease. However, the mechanism of the abnormal aggregation of Aβ in vivo is not well understood. Accu...

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Detalhes bibliográficos
Autor principal: Matsuzaki, Katsumi
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE-Hindawi Access to Research 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034960/
https://ncbi.nlm.nih.gov/pubmed/21318142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/956104
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