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A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity
Human embryonic stem (hES) cells show an atypical cell cycle regulation characterized by a high proliferation rate and a short G1-phase [1, 2]. In fact, a shortened G1-phase might protect ES cells from external signals inducing differentiation, as shown for certain stem cells [3]. It has been sugges...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3034649/ https://ncbi.nlm.nih.gov/pubmed/21167714 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2010.11.049 |
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