A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity

Human embryonic stem (hES) cells show an atypical cell cycle regulation characterized by a high proliferation rate and a short G1-phase [1, 2]. In fact, a shortened G1-phase might protect ES cells from external signals inducing differentiation, as shown for certain stem cells [3]. It has been sugges...

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Main Authors: Ruiz, Sergio, Panopoulos, Athanasia D., Herrerías, Aída, Bissig, Karl-Dimiter, Lutz, Margaret, Berggren, W. Travis, Verma, Inder M., Belmonte, Juan Carlos Izpisua
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034649/
https://ncbi.nlm.nih.gov/pubmed/21167714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2010.11.049
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