Epigenetic silencing of engineered L1 retrotransposition events in human embryonic carcinoma cells

Long INterspersed Element-1 (LINE-1 or L1) retrotransposition continues to impact human genome evolution1,2. L1s can retrotranspose in the germline, during early development, and in select somatic cells3,4,5,6,7,8; however, the host response to L1 retrotransposition remains largely unexplored. Here,...

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Main Authors: Garcia-Perez, Jose L., Morell, Maria, Scheys, Joshua O., Kulpa, Deanna A., Morell, Santiago, Carter, Christoph C., Hammer, Gary D., Collins, Kathleen L., O’Shea, K. Sue, Menendez, Pablo, Moran, John V.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034402/
https://ncbi.nlm.nih.gov/pubmed/20686575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09209
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