Effects of Vinylphosphonate Internucleotide Linkages on the Cleavage Specificity of Exonuclease III and on the Activity of DNA Polymerase I

We have previously reported the synthesis of vinylphosphonate-linked thymidine dimers and their incorporation into synthetic oligonucleotides to create vinylphosphonate internucleotide linkages in the DNA. Such linkages have a profound effect on DNA backbone rotational flexibility, and we have shown...

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Hauptverfasser: Doddridge, Zara A., Bertram, Richard D., Hayes, Christopher J., Soultanas, Panos
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2003
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034317/
https://ncbi.nlm.nih.gov/pubmed/12641455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi026985+
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