Structural Differences among Hemagglutinins of Influenza A Virus Subtypes Are Reflected in Their Antigenic Architecture: Analysis of H9 Escape Mutants

We used a panel of monoclonal antibodies to H9 hemagglutinin to select 18 escape mutants of mouse-adapted influenza A/Swine/Hong Kong/9/98 (H9N2) virus. Cross-reactions of the mutants with the antibodies and the sequencing of hemagglutinin genes revealed two minimally overlapping epitopes. We mapped...

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Hlavní autoři: Kaverin, Nikolai V., Rudneva, Irina A., Ilyushina, Natalia A., Lipatov, Aleksandr S., Krauss, Scott, Webster, Robert G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2004
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC303415/
https://ncbi.nlm.nih.gov/pubmed/14671105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.1.240-249.2004
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