Immune Failure in the Absence of Profound CD4(+) T-Lymphocyte Depletion in Simian Immunodeficiency Virus-Infected Rapid Progressor Macaques

A fraction of simian immunodeficiency virus (SIV)-infected macaques develop rapidly progressive disease in the apparent absence of detectable SIV-specific antibody responses. To characterize the immunopathogenesis of this syndrome, we studied viral load, CD4(+) T-lymphocyte numbers as well as cellul...

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Main Authors: Hirsch, Vanessa M., Santra, Sampa, Goldstein, Simoy, Plishka, Ronald, Buckler-White, Alicia, Seth, Aruna, Ourmanov, Ilnour, Brown, Charles R., Engle, Ronald, Montefiori, David, Glowczwskie, Jennifer, Kunstman, Kevin, Wolinsky, Steven, Letvin, Norman L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2004
Teme:
Pathogenesis and Immunity
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC303408/
https://ncbi.nlm.nih.gov/pubmed/14671109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.1.275-284.2004
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