Epstein-Barr Virus Immediate-Early Protein BZLF1 Inhibits Tumor Necrosis Factor Alpha-Induced Signaling and Apoptosis by Downregulating Tumor Necrosis Factor Receptor 1

Tumor necrosis factor alpha (TNF-α) is a key mediator of host immune and inflammatory responses and inhibits herpesvirus replication by cytolytic and noncytolytic mechanisms. TNF-α effects are primarily mediated through the major TNF-α receptor, TNF-R1, which is constitutively expressed in most cell...

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Detalles Bibliográficos
Main Authors: Morrison, Thomas E., Mauser, Amy, Klingelhutz, Aloysius, Kenney, Shannon C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2004
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC303403/
https://ncbi.nlm.nih.gov/pubmed/14671137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.1.544-549.2004
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