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Oral TNF-α Gene Silencing using a Polymeric Microsphere-Based Delivery System for the Treatment of Inflammatory Bowel Disease
The purpose of this study was to evaluate down-regulation of tumor necrosis factor (TNF)-α by oral RNA interference therapy. Control (scrambled sequence) or TNF-α specific small interfering RNA (siRNA) was encapsulated in type B gelatin nanoparticles and further entrapped in poly(epsilon-caprolacton...
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| Principais autores: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3033993/ https://ncbi.nlm.nih.gov/pubmed/20959130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2010.10.002 |
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