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Multiple shRNA combinations for near-complete coverage of all HIV-1 strains

BACKGROUND: Combinatorial RNA interference (co-RNAi) approaches are needed to account for viral variability in treating HIV-1 with RNAi, as single short hairpin RNAs (shRNA) are rapidly rendered ineffective by resistant strains. Current work suggests that 4 simultaneously expressed shRNAs may preven...

詳細記述

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書誌詳細
主要な著者: Mcintyre, Glen J, Groneman, Jennifer L, Yu, Yi-Hsin, Tran, Anna, Applegate, Tanya L
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033792/
https://ncbi.nlm.nih.gov/pubmed/21226969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-6405-8-1
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