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Initial Development and Validation of a Novel Extraction Method for Quantitative Mining of the Formalin-Fixed, Paraffin-Embedded Tissue Proteome for Biomarker Investigations

[Image: see text] Annotated formalin-fixed, paraffin-embedded (FFPE) tissue archives constitute a valuable resource for retrospective biomarker discovery. However, proteomic exploration of archival tissue is impeded by extensive formalin-induced covalent cross-linking. Robust methodology enabling pr...

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Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Nirmalan, Niroshini J., Hughes, Christopher, Peng, Jianhe, McKenna, Therese, Langridge, James, Cairns, David A., Harnden, Patricia, Selby, Peter J., Banks, Rosamonde E.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Chemical Society 2010
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033703/
https://ncbi.nlm.nih.gov/pubmed/21117664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr100812d
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