Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial

BACKGROUND: Severe malaria is a major cause of childhood death and often the main reason for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established treatment of choice, although evidence from Asia suggests that artesunate is associated with a lower mortality. We compar...

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Main Authors: Dondorp, Arjen M, Fanello, Caterina I, Hendriksen, Ilse CE, Gomes, Ermelinda, Seni, Amir, Chhaganlal, Kajal D, Bojang, Kalifa, Olaosebikan, Rasaq, Anunobi, Nkechinyere, Maitland, Kathryn, Kivaya, Esther, Agbenyega, Tsiri, Nguah, Samuel Blay, Evans, Jennifer, Gesase, Samwel, Kahabuka, Catherine, Mtove, George, Nadjm, Behzad, Deen, Jacqueline, Mwanga-Amumpaire, Juliet, Nansumba, Margaret, Karema, Corine, Umulisa, Noella, Uwimana, Aline, Mokuolu, Olugbenga A, Adedoyin, Olanrewaju T, Johnson, Wahab BR, Tshefu, Antoinette K, Onyamboko, Marie A, Sakulthaew, Tharisara, Ngum, Wirichada Pan, Silamut, Kamolrat, Stepniewska, Kasia, Woodrow, Charles J, Bethell, Delia, Wills, Bridget, Oneko, Martina, Peto, Tim E, von Seidlein, Lorenz, Day, Nicholas PJ, White, Nicholas J
Format: Artigo
Language:Inglês
Published: Lancet Publishing Group 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033534/
https://ncbi.nlm.nih.gov/pubmed/21062666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(10)61924-1
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