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PKCγ is required for ethanol-induced increases in GABA(A) receptor α4 subunit expression in cultured cerebral cortical neurons

Ethanol exposure produces alterations in GABA(A) receptor function and expression associated with CNS hyperexcitability, but the mechanisms of these effects are unknown. Ethanol is known to increase both GABA(A) receptor α4 subunits and protein kinase C (PKC) isozymes in vivo and in vitro. Here, we...

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Autors principals: Werner, David F., Kumar, Sandeep, Criswell, Hugh E., Suryanarayanan, Asha, Fetzer, J. Alex, Comerford, Chris E., Morrow, A. Leslie
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033448/
https://ncbi.nlm.nih.gov/pubmed/21155805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2010.07140.x
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