Ethanol Reduces GABA(A) α1 Subunit Receptor Surface Expression by a Protein Kinase Cγ-Dependent Mechanism in Cultured Cerebral Cortical Neurons

Prolonged ethanol exposure causes central nervous system hyperexcitability that involves a loss of GABAergic inhibition. We previously demonstrated that long-term ethanol exposure enhances the internalization of synaptic GABA(A) receptors composed of α1β2/3γ2 subunits. However, the mechanisms of eth...

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Auteurs principaux: Kumar, Sandeep, Suryanarayanan, Asha, Boyd, Kevin N., Comerford, Chris E., Lai, Marvin A., Ren, Qinglu, Morrow, A. Leslie
Format: Artigo
Langue:Inglês
Publié: The American Society for Pharmacology and Experimental Therapeutics 2010
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872966/
https://ncbi.nlm.nih.gov/pubmed/20159950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.063016
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