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A New Testing Strategy to Identify Rare Variants with Either Risk or Protective Effect on Disease

Rapid advances in sequencing technologies set the stage for the large-scale medical sequencing efforts to be performed in the near future, with the goal of assessing the importance of rare variants in complex diseases. The discovery of new disease susceptibility genes requires powerful statistical m...

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Detalhes bibliográficos
Main Authors: Ionita-Laza, Iuliana, Buxbaum, Joseph D., Laird, Nan M., Lange, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033379/
https://ncbi.nlm.nih.gov/pubmed/21304886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001289
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