Pharmacodynamic Modeling of Anti-Cancer Activity of Tetraiodothyroacetic Acid in a Perfused Cell Culture System

Unmodified or as a poly[lactide-co-glycolide] nanoparticle, tetraiodothyroacetic acid (tetrac) acts at the integrin αvβ3 receptor on human cancer cells to inhibit tumor cell proliferation and xenograft growth. To study in vitro the pharmacodynamics of tetrac formulations in the absence of and in con...

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Hlavní autoři: Lin, Hung-Yun, Landersdorfer, Cornelia B., London, David, Meng, Ran, Lim, Chang-Uk, Lin, Cassie, Lin, Sharon, Tang, Heng-Yuan, Brown, David, Van Scoy, Brian, Kulawy, Robert, Queimado, Lurdes, Drusano, George L., Louie, Arnold, Davis, Faith B., Mousa, Shaker A., Davis, Paul J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033367/
https://ncbi.nlm.nih.gov/pubmed/21304935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1001073
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