Pharmacodynamic Modeling of Anti-Cancer Activity of Tetraiodothyroacetic Acid in a Perfused Cell Culture System

Unmodified or as a poly[lactide-co-glycolide] nanoparticle, tetraiodothyroacetic acid (tetrac) acts at the integrin αvβ3 receptor on human cancer cells to inhibit tumor cell proliferation and xenograft growth. To study in vitro the pharmacodynamics of tetrac formulations in the absence of and in con...

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Detalhes bibliográficos
Main Authors: Lin, Hung-Yun, Landersdorfer, Cornelia B., London, David, Meng, Ran, Lim, Chang-Uk, Lin, Cassie, Lin, Sharon, Tang, Heng-Yuan, Brown, David, Van Scoy, Brian, Kulawy, Robert, Queimado, Lurdes, Drusano, George L., Louie, Arnold, Davis, Faith B., Mousa, Shaker A., Davis, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033367/
https://ncbi.nlm.nih.gov/pubmed/21304935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1001073
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